Marx - Are you gonna post that in every thread where someone asks for some generic stream info? I understand your point, and agree for the most part, but I don't think anyone is going to give out any hidden gems here. The guy (who is new to the area) asked a fairly benign question, and a nudge in the right direction isn't gonna hurt anything.
rscheckler - I lived in Htown for a couple years right outta college. Cool town and I miss it a lot. My wife's commute to Reading was too far though so we ended up moving to Lebanon County. I'll second the recommendation on the Warwick...great hot Roast Beef Sandwich. We still go there a couple times a year.
As far as streams go, the Swatara (which basically almost encircles Htown) is an excellent warm-water fishery. Smallies, Rock Bass, Fallfish, and Redbreasts are all present in good numbers, along with the occasional Musky and Pickeral. Obviously it's better fishing for these species in the warmer months, but once the weather warms, you're living right next to a very good warmwater stream. I used to walk to the creek after work most days in the Summer. Easy access in Hummelstown along the Hummel Nature Trail and at the Duke Street bridge. If you're willing to drive a bit, there's more spots in Lebanon County with easy access too...Harpers Tavern, Waterworks, Jonestown, and Swatara State Park to name a few.
As far as trout goes, locally Manada and the Quittapahilla (Quittie) are both decent options as the other guys have mentioned. Both have DHALO stretches, and both fish pretty well throughout the year. Manada (downstream of the DHALO section) has some mild thermal issues in the Summer but still has a moderate population of wild Browns in its upper reaches on top of the stockies. The Quittie is a degraded limestone stream, but still manages to stay cool in the Summer, and generally holds over a good bit of fish. A few posters believe there is some very limited natural reproduction taking place there too, which is definitely possible.
Check out the links Marx posted too, especially the nat repro list. Plenty of good streams on that list within an hours drive in any direction. Pick a few that are close together and go exploring for a day, see what you turn up. Most streams in the area hold something...if not trout, at least some Sunnies and Smallies usually.
That, along with the other posts should get ya started. Good fishing to be had in the area, welcome!