Here are some lodging options:
http://www.sprucecreekoutfitters.org/lodging.htm
That linked, I would not look as far as State College or Huntingdon, but rather look up "Tyrone Motels" on Google, unless you want to fish the State Collge streams as well.
Spruce Creek enters the Little J at Spruce Creek, PA. Downstream from where Rte 45 crosses the river is private land on both sides of the river, controlled by SRC. You can access the water legally above the bridge, but not across any land below it. The SRC land runs downstream at least a couple miles, maybe more. The next downstream access is at Rothrock State Forest property in Barree, PA. If you were to walk upstream a couple miles from there, you would encounter lands controlled by SRC. Below Barree and above Spruce Creek is mostly open. Private lands along the river should be posted if the landowner objects to your accessing it. Good luck.