In 2008, when I hiked it (Meml Day weekend in fact), Pleasant Run was knee deep, fast, and very cold. It's along a dirt road, so not sure I'd want to camp there, at least with a backpack.
As for other streams, the OLP follows Rock Run a bit, but that stream is a rock chute, very pretty but few fish and maybe AMD -- reports here say some tribs have natives. On the trail leading to Pleasant Run was a nice little stream named Long Run (?). On the OLP several miles south of Pleasant Run, there is a fantastic vista.
Trail reports say Pleasant Run Road may be closed in one spot -- might want to call to check where the closure is.