In additon to the great muskie fishing on the Susqie and Schuylkill River, there are many small lakes with public access in Central PA that support good numbers of muskies. I usually fish from my canoe or, if I'm lucky, my Dad spends the morning and/or evening propelling me around in his jonboat w/ a trolling motor.
Like most predatory fish, they are most agressive in low light conditions. In the spring, find sheltered bays with clean bottoms which provide spawning grounds. If these spawners nest are challenged by a large baitfish imitation, get ready for a furious explosion.
In summer look for drop-offs from shallow to deep water. The muskie will hold deeper and swim up to attack baitfish.
Fall fishing should find you casting to weedlines in more shallow water. Mushies get very aggressive this time of year as they are feeding to prepare for winter.
I use a 9ft, 9wt Temple Fork TiCrx with an Orvis Mach series reel. The fast action 9wt makes casting large flies less tiring and if you hook up you will be happy to have large arbor, great drag, plenty of backing and a powerful rod. I use floating line for shallow water fishing and a striper intermediate for deep water. Large flies, size 3/0 to 6/0 to match the baitfish available. Be sure to use some kind of wire bite guard. I like the Tyger wire, as it ties knots and I can decide my wire length, usually about 4 inches.
Have a boga grip or lippa grip and pliers, DO NOT fool with the teeth! I'm not kidding! Don't be suprised if you catch some lunker bass using these same tactics. Site fishing the shallows in spring and fall are my favorite and have been most productive.