Possibilities are pretty extensive with that range, almost endless. I don't know what timeframe you're looking in, but I'll assume the next month or so.
You've got all of the central PA streams (Penns, Spring, Little J, Fishing Creek, etc) as one option. You could stay in one location and fish any number of streams.
You've also got the Upper Delaware/etc system. E & W branches, main stem not to mention Beaverkill, Willowemoc, Neversink and Esopus also right there.
If you're willing to drive 5 hours, you could head up to the Salmon River and head out for kings, coho and/or steelhead.